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51st ERA-EDTA CONGRESS

 

31 May - 3 June 2014 AMSTERDAM
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Discussion forum - 51st ERA-EDTA CONGRESS
    Topic - I) Diabetes. I1) Basic research in diabetes.

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Poster: 303
Visits: 19
Title: GLUCOSAMINE-STIMULATED ENDOPLASMIC RETICULUM STRESS AND AUTOPHAGY ARE ASSOCIATED WITH INSULIN RESISTANCE OF RAT CULTURED PODOCYTES
Authors: Dorota Rogacka ,
Centre: Mossakowski Medical Research Centre, Polish Academy of Science

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GLUCOSAMINE-STIMULATED ENDOPLASMIC RETICULUM STRESS AND AUTOPHAGY ARE ASSOCIATED WITH INSULIN RESISTANCE OF RAT CULTURED PODOCYTES

Dorota Rogacka
Thread initiator
Subspeciality
Reg: 4/25/2013 3:38:00 PM
Comment# 1
Podocytes are direct targets for insulin, and insulin signaling is essential for normal glomerular function. Disturbances in insulin signaling accompanied by insulin resistance can lead to various intracellular events. Excessive flux through the hexosamine biosynthetic pathway (HBP) and endoplasmic reticulum (ER) stress were related to insulin resistance. The endoplasmic reticulum (ER) plays a key role in the synthesis and modification of secretory and membrane proteins in all eukaryotic cells. Stress in the endoplasmic reticulum (ER) results from insufficient protein folding capacity or altered ER homeostasis by activating the unfolded protein response (UPR). Autophagy serves as a protective response during ER stress through the degradation of unfolded proteins and damaged organelles. We hypothesized that glucosamine-induced insulin resistance in podocytes is associated with ER stress stimulation accompanied by induction of autophagy.

Comment added on 5/19/2014 12:14:00 PM 
     
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Most viewed poster for this congress
Poster: 7
Visits: 477
Title: SEVERE SYMPTOMATIC ACUTE HYPONATREMIA IN TRAUMATIC BRAIN INJURY RESPONDS VERY RAPIDLY SINGLE 15 MG DOSE OF TOLVAPTAN: A MAYO CLINIC HEALTH SYSTEM HOSPITAL EXPERIENCE - NEED FOR CAUTION WITH TOLVAPTAN IN YOUNGER PATIENTS WITH PRESERVED RENAL FUNCTION
Authors: MACAULAY ONUIGBO ,
Centre: MAYO CLINIC, ROCHESTER & MAYO CLINIC HEALTH SYSTEM, EAU CLAIRE

Poster most viewed in this topic
Poster: 297
Visits: 61
Title: EFFECTS OF TCV-116 (CANDESARTAN CILEXETIL) ON RENAL FUNCTION AND OXIDATIVE STRESS IN DIABETIC NRF2-DEFICIENT MICE
Authors: AKI HIRAYAMA ,
Centre: Center for Integrative Medicine, Tsukuba University of Technology


 








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